Tranexamic acid injections are used in obstetrics to control postpartum Tranexamic Acid Injections hemorrhage—a leading cause of maternal mortality worldwide. They help minimize blood loss and reduce the need for surgical interventions.
5. Hereditary Bleeding Disorders
Patients with conditions like hemophilia or von Willebrand disease may receive tranexamic acid before or after procedures such as dental extractions to manage bleeding tendencies.
Cosmetic and Off-Label Uses
Tranexamic acid has also gained popularity in dermatology. Although this use is off-label and more commonly in oral or topical form, IV tranexamic acid has occasionally been used in clinical settings for melasma and hyperpigmentation, due to its anti-inflammatory and melanin-inhibiting properties. However, its safety and efficacy for such purposes are still under study.
Dosage and Duration
The dosage of tranexamic acid injections varies by medical need and patient condition. For instance:
Surgical bleeding: 10–15 mg/kg IV before the procedure, repeated every 6–8 hours.
Trauma: 1 g IV over 10 minutes, followed by 1 g over 8 hours.
Menorrhagia: Dosing is adjusted based on severity and may require combination with oral therapy.
Physicians must consider factors such as renal function, age, and the presence of thromboembolic risk before prescribing or adjusting dosages.
Side Effects and Precautions
While tranexamic acid is generally well-tolerated, it may cause some side effects:
Common: Nausea, vomiting, muscle cramps, dizziness, and injection site pain.
Serious: Visual disturbances, allergic reactions, and rare cases of thromboembolism (e.g., deep vein thrombosis, stroke).
Patients with a history of blood clots, kidney impairment, or seizure disorders must use tranexamic acid with caution. Routine monitoring may be necessary during long-term or high-dose use.
Conclusion
Tranexamic acid injections and IV solutions are powerful tools in modern medicine, offering effective control over a range of bleeding conditions.