What Is Leucovorin?

Leucovorin (also called folinic acid) is a form of folate (vitamin B9 derivative) that bypasses some of the metabolic steps required by folic acid. It’s traditionally used in medicine to rescue healthy cells from high-dose methotrexate toxicity in cancer therapy Mayo Clinic+1. Leucovorin helps mitigate side effects by supplying reduced folate that the body can use directly.

Emerging Interest in Neurodevelopment

In recent years, scientists have explored whether leucovorin may be beneficial in cases of cerebral folate deficiency (CFD) — a condition in which there is insufficient transport of folate into the brain, leading to neurological symptoms. Some individuals with CFD present autistic features, cognitive delays, seizures, or movement disorders U.S. Food and Drug Administration.

In September 2025, the FDA initiated action to approve leucovorin calcium tablets for cerebral folate deficiency, based on case reports and mechanistic studies from 2009–2024. The approval process is currently focused on ensuring patient safety and clarity on effective dosing. U.S. Food and Drug Administration

How Leucovorin Works

• Bypasses metabolic steps: Unlike folic acid, leucovorin does not rely on dihydrofolate reductase to convert into usable forms, thus it can be effective even when that enzyme is inhibited. Wikipedia+1
• Supports neurochemical balance: In individuals with disturbances of folate transport, leucovorin may help supply methylation and one-carbon pathway intermediates needed for brain function.
• Adjunctive, not stand-alone: It is not a replacement for behavioral therapies; rather, leucovorin is considered a complementary approach under medical care.

Risks, Side Effects & Cautions

As with any medication, there are important safety considerations:

• Not to be used in vitamin B12 deficiency without caution (can worsen neurological damage) MedlinePlus+1
• Potential interaction with chemotherapy agents or folate antagonists
• Side effects may include allergic reactions, gastrointestinal discomfort, and in rare cases neurologic effects Drugs.com+2Cleveland Clinic+2
• Intrathecal (spinal) administration is contraindicated, and dosing must be guided by specialists NCBI+1

Relevance for Families in San Juan, La Dona, and Doña Ana Counties

For families in San Juan County (Farmington, Aztec) and Doña Ana County (Las Cruces, Hatch), access to credible, localized information on emerging therapies is limited. Absolute Autism Therapy’s interest in leucovorin reflects a commitment to providing up-to-date resources to families in more rural or underserved regions of New Mexico.

Integrating Leucovorin with Behavioral Care

If a child is being medically evaluated for leucovorin, behavioral interventions like ABA therapy remain crucial. Absolute Autism Therapy’s approach emphasizes synergy — behavioral strategies continue as the primary framework, with any medical adjunct explored responsibly and monitored carefully.  Check out this blog post that focuses SPECIFICALLY on the use of Leucovorin with ABA Therapy in the counties of San Juan, Dona Ana, and La Dona in Albuquerque, New Mexico.